Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.

Barbier, Ann J; Aluisio, Leah; Lord, Brian; Qu, Ying; Wilson, Sandy J; Boggs, Jamin D; Bonaventure, Pascal; Miller, Kirsten; Fraser, Ian; Dvorak, Lisa; Pudiak, Cindy; Dugovic, Christine; Shelton, Jonathan; Mazur, Curt; Letavic, Michael A; Carruthers, Nicholas I; Lovenberg, Timothy W

Barbier, Ann J; Aluisio, Leah; Lord, Brian; Qu, Ying; Wilson, Sandy J; Boggs, Jamin D; Bonaventure, Pascal; Miller, Kirsten; Fraser, Ian; Dvorak, Lisa; Pudiak, Cindy; Dugovic, Christine; Shelton, Jonathan; Mazur, Curt; Letavic, Michael A; Carruthers, Nicholas I; Lovenberg, Timothy W.

Affiliation

Barbier AJ; Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.

Eur J Pharmacol ; 576(1-3): 43-54, 2007 Dec 08.

Article in En | MEDLINE | ID: mdl-17765221

Subject(s)

Histamine Antagonists/pharmacology; Receptors, Histamine H3/metabolism; Selective Serotonin Reuptake Inhibitors/pharmacology; Tetrahydroisoquinolines/pharmacology; Animals; Brain/drug effects; Brain/metabolism; CHO Cells; Cell Line; Cricetinae; Cricetulus; Dogs; Dopamine Plasma Membrane Transport Proteins/metabolism; Histamine Antagonists/pharmacokinetics; Humans; Male; Mice; Mice, Inbred BALB C; Norepinephrine Plasma Membrane Transport Proteins/metabolism; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins/metabolism; Selective Serotonin Reuptake Inhibitors/pharmacokinetics; Tetrahydroisoquinolines/pharmacokinetics

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Database: MEDLINE Main subject: Selective Serotonin Reuptake Inhibitors / Receptors, Histamine H3 / Tetrahydroisoquinolines / Histamine Antagonists Limits: Animals / Humans / Male Language: En Year: 2007 Type: Article

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