Synthesis of some tropane derivatives of anticipated activity on the reuptake of norepinephrine and/or serotonin.

Hanna, Mona M; Eid, Nahed M; George, Riham F; Safwat, Hani M

Hanna, Mona M; Eid, Nahed M; George, Riham F; Safwat, Hani M.

Affiliation

Hanna MM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Bioorg Med Chem ; 15(24): 7765-72, 2007 Dec 15.

Article in En | MEDLINE | ID: mdl-17870537

Subject(s)

Norepinephrine Plasma Membrane Transport Proteins/metabolism; Norepinephrine/pharmacology; Selective Serotonin Reuptake Inhibitors/chemical synthesis; Serotonin Plasma Membrane Transport Proteins/metabolism; Serotonin/pharmacology; Tropanes/chemical synthesis; 5-Hydroxytryptophan/toxicity; Adrenergic alpha-Antagonists/toxicity; Animals; Citalopram/chemical synthesis; Citalopram/chemistry; Clomipramine/chemical synthesis; Clomipramine/chemistry; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluoxetine/chemical synthesis; Fluoxetine/chemistry; Mice; Molecular Structure; Norepinephrine Plasma Membrane Transport Proteins/drug effects; Serotonin Plasma Membrane Transport Proteins/drug effects; Selective Serotonin Reuptake Inhibitors/pharmacology; Tropanes/chemistry; Tropanes/pharmacology; Yohimbine/antagonists & inhibitors; Yohimbine/toxicity

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Tropanes / Serotonin / Norepinephrine / Selective Serotonin Reuptake Inhibitors / Norepinephrine Plasma Membrane Transport Proteins / Serotonin Plasma Membrane Transport Proteins Limits: Animals Language: En Year: 2007 Type: Article

Search on Google

XML

PubMed Links