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The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD.
Brown, Alan D; Bunnage, Mark E; Glossop, Paul A; Holbrook, Mark; Jones, Rhys D; Lane, Charlotte A L; Lewthwaite, Russell A; Mantell, Simon; Perros-Huguet, Christelle; Price, David A; Webster, Rob.
Affiliation
  • Brown AD; Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent, UK.
Bioorg Med Chem Lett ; 17(22): 6188-91, 2007 Nov 15.
Article in En | MEDLINE | ID: mdl-17897826
ABSTRACT
The design and profile of a series of indole containing long acting beta(2)-adrenoceptor agonists is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue model demonstrates that analogues within this series have salmeterol-like duration of action with potential for long duration of action in humans.
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Database: MEDLINE Main subject: Asthma / Receptors, Adrenergic, beta-2 / Adrenergic beta-Agonists / Pulmonary Disease, Chronic Obstructive / Indoles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2007 Type: Article
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Database: MEDLINE Main subject: Asthma / Receptors, Adrenergic, beta-2 / Adrenergic beta-Agonists / Pulmonary Disease, Chronic Obstructive / Indoles Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2007 Type: Article