Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.
Nat Rev Mol Cell Biol
; 8(12): 1006-16, 2007 Dec.
Article
in En
| MEDLINE
| ID: mdl-17928811
ABSTRACT
The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.
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Database:
MEDLINE
Main subject:
Intranuclear Inclusion Bodies
Limits:
Animals
/
Humans
Language:
En
Year:
2007
Type:
Article