Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.

Xiang, Min Amy; Rybczynski, Philip J; Patel, Mona; Chen, Robert H; McComsey, David F; Zhang, Han-Cheng; Gunnet, Joseph W; Look, Richard; Wang, Yuanping; Minor, Lisa K; Zhong, H Marlon; Villani, Frank J; Demarest, Keith T; Damiano, Bruce P; Maryanoff, Bruce E

Xiang, Min Amy; Rybczynski, Philip J; Patel, Mona; Chen, Robert H; McComsey, David F; Zhang, Han-Cheng; Gunnet, Joseph W; Look, Richard; Wang, Yuanping; Minor, Lisa K; Zhong, H Marlon; Villani, Frank J; Demarest, Keith T; Damiano, Bruce P; Maryanoff, Bruce E.

Affiliation

Xiang MA; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, 8 Clarke Drive, Cranbury, NJ 08512, USA.

Bioorg Med Chem Lett ; 17(23): 6623-8, 2007 Dec 01.

Article in En | MEDLINE | ID: mdl-17942308

Subject(s)

Antidiuretic Hormone Receptor Antagonists; Benzazepines/chemistry; Spiro Compounds/chemistry; Animals; Antihypertensive Agents/administration & dosage; Antihypertensive Agents/chemistry; Antihypertensive Agents/metabolism; Antihypertensive Agents/pharmacokinetics; Benzazepines/administration & dosage; Benzazepines/pharmacokinetics; Benzazepines/pharmacology; Drug Evaluation, Preclinical; Female; Humans; Male; Rats; Rats, Long-Evans; Receptors, Vasopressin/metabolism; Receptors, Vasopressin/physiology; Spiro Compounds/administration & dosage; Spiro Compounds/metabolism; Spiro Compounds/pharmacokinetics; Spiro Compounds/pharmacology; Vasopressins/metabolism

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Database: MEDLINE Main subject: Spiro Compounds / Benzazepines / Antidiuretic Hormone Receptor Antagonists Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2007 Type: Article

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