Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors.

Lee, Cheng-Chung; Kuo, Chih-Jung; Hsu, Min-Feng; Liang, Po-Huang; Fang, Jim-Min; Shie, Jiun-Jie; Wang, Andrew H-J

Lee, Cheng-Chung; Kuo, Chih-Jung; Hsu, Min-Feng; Liang, Po-Huang; Fang, Jim-Min; Shie, Jiun-Jie; Wang, Andrew H-J.

Affiliation

Lee CC; Structural Biology Program, Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan.

FEBS Lett ; 581(28): 5454-8, 2007 Nov 27.

Article in En | MEDLINE | ID: mdl-17981158

Subject(s)

Protease Inhibitors/chemistry; Protease Inhibitors/pharmacology; Severe acute respiratory syndrome-related coronavirus/enzymology; Viral Proteins/antagonists & inhibitors; Coronavirus 3C Proteases; Cysteine Endopeptidases/chemistry; Cysteine Endopeptidases/genetics; Cysteine Endopeptidases/metabolism; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Viral Proteins/chemistry; Viral Proteins/genetics; Viral Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Protease Inhibitors / Viral Proteins / Severe acute respiratory syndrome-related coronavirus Language: En Year: 2007 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Protease Inhibitors / Viral Proteins / Severe acute respiratory syndrome-related coronavirus Language: En Year: 2007 Type: Article