Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

Regard, Jean B; Kataoka, Hiroshi; Cano, David A; Camerer, Eric; Yin, Liya; Zheng, Yao-Wu; Scanlan, Thomas S; Hebrok, Matthias; Coughlin, Shaun R

Regard, Jean B; Kataoka, Hiroshi; Cano, David A; Camerer, Eric; Yin, Liya; Zheng, Yao-Wu; Scanlan, Thomas S; Hebrok, Matthias; Coughlin, Shaun R.

Affiliation

Regard JB; Cardiovascular Research Institute, Diabetes Center, Department of Cellular and Molecular Pharmacology, UCSF School of Medicine, San Francisco, California 94143-2240, USA.

J Clin Invest ; 117(12): 4034-43, 2007 Dec.

Article in En | MEDLINE | ID: mdl-17992256

Subject(s)

GTP-Binding Protein alpha Subunits, Gi-Go/metabolism; Glucose/metabolism; Insulin/metabolism; Pertussis Toxin/biosynthesis; Receptors, G-Protein-Coupled/metabolism; Signal Transduction; Animals; GTP-Binding Protein alpha Subunits, Gi-Go/genetics; Insulin Secretion; Integrases/genetics; Mice; Mice, Transgenic; Organ Specificity/genetics; Pertussis Toxin/genetics; Proteins/genetics; Quantitative Trait Loci/genetics; RNA, Untranslated; Receptors, G-Protein-Coupled/genetics; Signal Transduction/genetics; Thyronines/metabolism

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / GTP-Binding Protein alpha Subunits, Gi-Go / Pertussis Toxin / Receptors, G-Protein-Coupled / Glucose / Insulin Type of study: Prognostic_studies Limits: Animals Language: En Year: 2007 Type: Article

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