Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities.

Samandari, Elika; Kempná, Petra; Nuoffer, Jean-Marc; Hofer, Gaby; Mullis, Primus E; Flück, Christa E

Samandari, Elika; Kempná, Petra; Nuoffer, Jean-Marc; Hofer, Gaby; Mullis, Primus E; Flück, Christa E.

Affiliation

Samandari E; Pediatric Endocrinology and Diabetology, University Children's Hospital Bern, Freiburgstrasse 15, G3 812, 3010 Bern, Switzerland.

J Endocrinol ; 195(3): 459-72, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18000308

Subject(s)

3-Hydroxysteroid Dehydrogenases/metabolism; Adrenal Cortex Neoplasms/metabolism; Androgens/biosynthesis; Carcinoma/metabolism; Steroid 17-alpha-Hydroxylase/metabolism; 8-Bromo Cyclic Adenosine Monophosphate/pharmacology; Adrenal Cortex Neoplasms/pathology; Adrenocorticotropic Hormone/metabolism; Adrenocorticotropic Hormone/pharmacology; Angiotensin II/pharmacology; Carcinoma/pathology; Cell Line, Tumor; Cyclic AMP/metabolism; Enzymes/genetics; Enzymes/metabolism; Gene Expression; Humans; Isoenzymes/metabolism; Receptor, Angiotensin, Type 1/metabolism; Receptor, Melanocortin, Type 2/metabolism; Signal Transduction

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PubMed Links

Database: MEDLINE Main subject: Carcinoma / Steroid 17-alpha-Hydroxylase / Adrenal Cortex Neoplasms / 3-Hydroxysteroid Dehydrogenases / Androgens Type of study: Prognostic_studies Limits: Humans Language: En Year: 2007 Type: Article

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