Age-related changes in cell surface antigens of preleukemic AKR thymocytes.
J Exp Med
; 144(1): 193-208, 1976 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-180229
ABSTRACT
Thymocytes from preleukemic AKR mice aged 5-6 mo have an altered pattern of cell surface antigens. The expression of four MuLV-related antigens on the cell surface (GIX, GCSA, gp70, p30) is markedly increased in comparison to 2-mo-old AKR mice and approximates the heightened levels of these antigens found on thymic leukemia cells. H-2 and Thy-1 alloantigens also show characteristic modifications in relation to age and leukemia development. In contrast to the high Thy-1/low H-2 levels on 2-mo-old AKR thymocytes, thymocytes from 6-mo-old mice and thymic leukemia cells frequently show a low Thy-1/high H-2 surface phenotype. As thymocytes from mouse strains with a low incidence of leukemia do not show these changes, they appear to represent a stage in the conversion of normal cells to leukemia cells.
Full text:
1
Database:
MEDLINE
Main subject:
Thymus Gland
/
Aging
/
Leukemia, Experimental
/
Mice, Inbred AKR
/
Antigens, Neoplasm
/
Antigens, Viral
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Year:
1976
Type:
Article