The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.

Tsai, Yien Che; Mendoza, Arnulfo; Mariano, Jennifer M; Zhou, Ming; Kostova, Zlatka; Chen, Bo; Veenstra, Timothy; Hewitt, Stephen M; Helman, Lee J; Khanna, Chand; Weissman, Allan M

Tsai, Yien Che; Mendoza, Arnulfo; Mariano, Jennifer M; Zhou, Ming; Kostova, Zlatka; Chen, Bo; Veenstra, Timothy; Hewitt, Stephen M; Helman, Lee J; Khanna, Chand; Weissman, Allan M.

Affiliation

Tsai YC; Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

Nat Med ; 13(12): 1504-9, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18037895

Subject(s)

Kangai-1 Protein/metabolism; Proteins/chemistry; Receptors, Cytokine/physiology; Sarcoma/pathology; Ubiquitin-Protein Ligases/physiology; Animals; Cell Line, Tumor; Endoplasmic Reticulum/metabolism; Humans; Mesoderm/metabolism; Mice; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; RING Finger Domains; Receptors, Autocrine Motility Factor; Receptors, Cytokine/genetics; Transfection; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism

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Database: MEDLINE Main subject: Sarcoma / Proteins / Receptors, Cytokine / Ubiquitin-Protein Ligases / Kangai-1 Protein Limits: Animals / Humans Language: En Year: 2007 Type: Article

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