Calreticulin/blood; Calreticulin/genetics; Hemochromatosis/genetics; Histocompatibility Antigens Class I/genetics; Histocompatibility Antigens Class I/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mutation, Missense; Adult; Aged; Animals; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/metabolism; Calreticulin/antagonists & inhibitors; Cell Line; Disease Models, Animal; Female; Gene Expression Regulation; Hemochromatosis/physiopathology; Hemochromatosis Protein; Hepatocytes/metabolism; Hepatocytes/pathology; Hepcidins; Humans; Male; Mice; Middle Aged; Monocytes/metabolism; Monocytes/pathology; Oxidative Stress; RNA, Messenger/analysis; RNA, Small Interfering/administration & dosage; Rats; Receptors, Transferrin/biosynthesis; Receptors, Transferrin/blood; Receptors, Transferrin/genetics; Transfection