Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients.

Eley, H L; Skipworth, R J E; Deans, D A C; Fearon, K C H; Tisdale, M J

Eley, H L; Skipworth, R J E; Deans, D A C; Fearon, K C H; Tisdale, M J.

Affiliation

Eley HL; Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.

Br J Cancer ; 98(2): 443-9, 2008 Jan 29.

Article in En | MEDLINE | ID: mdl-18087277

Subject(s)

Adenocarcinoma/complications; Eukaryotic Initiation Factor-2/metabolism; Gastrointestinal Neoplasms/complications; Muscle, Skeletal/pathology; Muscular Atrophy/etiology; Muscular Atrophy/metabolism; Weight Loss; eIF-2 Kinase/metabolism; Adenocarcinoma/metabolism; Adult; Aged; Aged, 80 and over; Cachexia/etiology; Cachexia/metabolism; Female; Gastrointestinal Neoplasms/metabolism; Humans; Male; Middle Aged; Models, Biological; Phosphorylation; Up-Regulation; Weight Loss/physiology

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Full text: 1 Database: MEDLINE Main subject: Muscular Atrophy / Adenocarcinoma / Weight Loss / Eukaryotic Initiation Factor-2 / Muscle, Skeletal / EIF-2 Kinase / Gastrointestinal Neoplasms Type of study: Etiology_studies / Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2008 Type: Article

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