Long-term control or possible cure? Treatment of stage D2 prostate cancer under chemotherapy using cisplatin and estramustine phosphate followed by maximal androgen blockade.
Int Urol Nephrol
; 40(2): 365-8, 2008.
Article
in En
| MEDLINE
| ID: mdl-18092143
ABSTRACT
Metastatic prostate cancer (PC) is incurable by androgen deprivation therapy alone, due to the presence of androgen-independent/supersensitive cells in hormone-naive PC. A 67-year-old man was diagnosed with PC (Gleason score, 5 + 4) with multiple bone metastases. He was treated by chemohormonal therapy with cisplatin and estramustine phosphate (EMP) followed by maximal androgen blockade, and showed a complete response. As of the time of writing, no clinical or prostate-specific antigen recurrence has been observed for over 15 years, despite cessation of the treatment. This is the first report to indicate a possible cure of metastatic PC by chemohormonal therapy combined with appropriate anti-tumor drugs targeted to both androgen-independent and -dependent clones before the hormone-refractory state.
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Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Cisplatin
/
Antineoplastic Agents, Hormonal
/
Estramustine
/
Androgen Antagonists
/
Antineoplastic Agents
Limits:
Aged
/
Humans
/
Male
Language:
En
Year:
2008
Type:
Article