Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

Xie, Zhonglin; Dong, Yunzhou; Scholz, Roland; Neumann, Dietbert; Zou, Ming-Hui

Xie, Zhonglin; Dong, Yunzhou; Scholz, Roland; Neumann, Dietbert; Zou, Ming-Hui.

Affiliation

Xie Z; Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Circulation ; 117(7): 952-62, 2008 Feb 19.

Article in En | MEDLINE | ID: mdl-18250273

Subject(s)

Endothelial Cells/drug effects; Hypoglycemic Agents/pharmacology; Metformin/pharmacology; Multienzyme Complexes/metabolism; Protein Kinase C/physiology; Protein Processing, Post-Translational/drug effects; Protein Serine-Threonine Kinases/metabolism; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Acetyl-CoA Carboxylase/metabolism; Active Transport, Cell Nucleus; Animals; Cattle; Cells, Cultured/drug effects; Cells, Cultured/enzymology; Codon/drug effects; Cytosol/enzymology; Endothelial Cells/enzymology; Enzyme Activation/drug effects; HeLa Cells/drug effects; HeLa Cells/enzymology; Humans; Phosphorylation/drug effects; Phosphoserine/metabolism; Point Mutation; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/genetics; Protein Serine-Threonine Kinases/genetics; Transduction, Genetic

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Full text: 1 Database: MEDLINE Main subject: Protein Kinase C / Protein Processing, Post-Translational / Protein Serine-Threonine Kinases / Endothelial Cells / Hypoglycemic Agents / Metformin / Multienzyme Complexes Limits: Animals / Humans Language: En Year: 2008 Type: Article

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