Short hairpin RNA-expressing oncolytic adenovirus-mediated inhibition of IL-8: effects on antiangiogenesis and tumor growth inhibition.

Yoo, J Y; Kim, J-H; Kim, J; Huang, J-H; Zhang, S N; Kang, Y-A; Kim, H; Yun, C-O

Yoo, J Y; Kim, J-H; Kim, J; Huang, J-H; Zhang, S N; Kang, Y-A; Kim, H; Yun, C-O.

Affiliation

Yoo JY; Brain Korea 21 Project for Medical Sciences, Institute for Cancer Research, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Gene Ther ; 15(9): 635-51, 2008 May.

Article in En | MEDLINE | ID: mdl-18273054

Subject(s)

Adenoviridae/genetics; Breast Neoplasms/therapy; Genetic Therapy/methods; Interleukin-8/genetics; Oncolytic Virotherapy/methods; RNA, Small Interfering/administration & dosage; Animals; Cell Line, Tumor; Endothelial Cells/metabolism; Female; Gene Silencing; Genetic Engineering; Humans; Interleukin-8/analysis; Interleukin-8/metabolism; Lung Neoplasms/secondary; Lung Neoplasms/therapy; Male; Matrix Metalloproteinase 2/analysis; Matrix Metalloproteinase 2/metabolism; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic/genetics; Promoter Regions, Genetic; RNA Interference; Transduction, Genetic/methods; Vascular Endothelial Growth Factor A/analysis; Vascular Endothelial Growth Factor A/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Genetic Therapy / Adenoviridae / Interleukin-8 / RNA, Small Interfering / Oncolytic Virotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2008 Type: Article

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