Development of a simplified assay for determination of the antimineralocorticoid activity of compounds dosed in rats.

Brandish, Philip E; Chen, Hongxing; Szczerba, Peter; Hershey, James C

Brandish, Philip E; Chen, Hongxing; Szczerba, Peter; Hershey, James C.

Affiliation

Brandish PE; Department of Molecular Endocrinology, Merck & Co., West Point, PA 19486, United States. philip_brandish@merck.com

J Pharmacol Toxicol Methods ; 57(2): 155-60, 2008.

Article in En | MEDLINE | ID: mdl-18304838

Subject(s)

Drug Evaluation, Preclinical/methods; Mineralocorticoid Receptor Antagonists; Aldosterone/pharmacology; Amiloride/pharmacology; Analysis of Variance; Animals; Creatinine/urine; Diuretics/pharmacology; Dose-Response Relationship, Drug; Eplerenone; Hydrochlorothiazide/pharmacology; Imidazoles/pharmacology; Male; Potassium/urine; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Mineralocorticoid/agonists; Receptors, Mineralocorticoid/metabolism; Sodium/urine; Spironolactone/analogs & derivatives; Spironolactone/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Drug Evaluation, Preclinical / Mineralocorticoid Receptor Antagonists Type of study: Guideline Limits: Animals Language: En Year: 2008 Type: Article

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