Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury.

Wu, Jun; Sun, Tian-Sheng; Ren, Ji-Xin; Wang, Xian-Zhang

Wu, Jun; Sun, Tian-Sheng; Ren, Ji-Xin; Wang, Xian-Zhang.

Affiliation

Wu J; Department of Orthopedics, Traumatic Orthopedic Institute of PLA, Beijing Army General Hospital, Beijing 100700, China.

Neurosci Bull ; 24(2): 57-65, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18369383

Subject(s)

Brain Tissue Transplantation/methods; Gene Transfer Techniques; Nerve Regeneration/genetics; Neuroglia/transplantation; Neurotrophin 3/genetics; Spinal Cord Injuries/therapy; Animals; Animals, Newborn; Cells, Cultured; DNA, Recombinant/therapeutic use; Disease Models, Animal; Female; Genetic Therapy/methods; Genetic Vectors/genetics; Graft Survival/genetics; Growth Cones/metabolism; Growth Cones/ultrastructure; Neuroglia/metabolism; Neurotrophin 3/biosynthesis; Olfactory Bulb/cytology; Olfactory Bulb/transplantation; Paralysis/metabolism; Paralysis/physiopathology; Paralysis/therapy; Plasmids/genetics; Rats; Rats, Wistar; Recovery of Function/genetics; Spinal Cord Injuries/metabolism; Spinal Cord Injuries/physiopathology; Treatment Outcome; Up-Regulation/genetics

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Full text: 1 Database: MEDLINE Main subject: Spinal Cord Injuries / Neuroglia / Brain Tissue Transplantation / Gene Transfer Techniques / Neurotrophin 3 / Nerve Regeneration Type of study: Prognostic_studies Limits: Animals Language: En Year: 2008 Type: Article

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