CYP2A6 and the plasma level of 5-chloro-2, 4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1.

Fujita, Ken-ichi; Yamamoto, Wataru; Endo, Shoji; Endo, Hisashi; Nagashima, Fumio; Ichikawa, Wataru; Tanaka, Ryuhei; Miya, Toshimichi; Araki, Kazuhiro; Kodama, Keiji; Sunakawa, Yu; Narabayashi, Masaru; Miwa, Keisuke; Ando, Yuichi; Akiyama, Yuko; Kawara, Kaori; Kamataki, Tetsuya; Sasaki, Yasutsuna

Fujita, Ken-ichi; Yamamoto, Wataru; Endo, Shoji; Endo, Hisashi; Nagashima, Fumio; Ichikawa, Wataru; Tanaka, Ryuhei; Miya, Toshimichi; Araki, Kazuhiro; Kodama, Keiji; Sunakawa, Yu; Narabayashi, Masaru; Miwa, Keisuke; Ando, Yuichi; Akiyama, Yuko; Kawara, Kaori; Kamataki, Tetsuya; Sasaki, Yasutsuna.

Affiliation

Fujita K; Department of Medical Oncology, Comprehensive Cancer Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.

Cancer Sci ; 99(5): 1049-54, 2008 May.

Article in En | MEDLINE | ID: mdl-18380793

Subject(s)

Antimetabolites, Antineoplastic/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/genetics; Fluorouracil/pharmacokinetics; Mixed Function Oxygenases/genetics; Oxonic Acid/pharmacokinetics; Pyridines/blood; Tegafur/pharmacokinetics; Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases/metabolism; Asian People; Cytochrome P-450 CYP2A6; Drug Combinations; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases/metabolism; Neoplasms/drug therapy; Polymorphism, Genetic

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Oxonic Acid / Pyridines / Aryl Hydrocarbon Hydroxylases / Tegafur / Fluorouracil / Mixed Function Oxygenases / Antimetabolites, Antineoplastic Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2008 Type: Article

Fulltext

XML

PubMed Links

Search on Google