Methadone: does it really have low efficacy at micro-opioid receptors?

Rodriguez-Martin, Ivan; Braksator, Ellen; Bailey, Chris P; Goodchild, Sam; Marrion, Neil V; Kelly, Eamonn; Henderson, Graeme

Rodriguez-Martin, Ivan; Braksator, Ellen; Bailey, Chris P; Goodchild, Sam; Marrion, Neil V; Kelly, Eamonn; Henderson, Graeme.

Affiliation

Rodriguez-Martin I; Department of Physiology and Pharmacology, University of Bristol, Bristol, UK.

Neuroreport ; 19(5): 589-93, 2008 Mar 26.

Article in En | MEDLINE | ID: mdl-18388744

Subject(s)

Methadone/pharmacology; Narcotics/pharmacology; Neurons/drug effects; Receptors, Opioid, mu/drug effects; Animals; Animals, Newborn; Cell Line, Transformed; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Humans; In Vitro Techniques; Locus Coeruleus/cytology; Membrane Potentials/drug effects; Membrane Potentials/physiology; Morphine/pharmacology; Naloxone/pharmacology; Narcotic Antagonists/pharmacology; Neurons/physiology; Neurons/radiation effects; Protein Binding/drug effects; Rats; Transfection

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Full text: 1 Database: MEDLINE Main subject: Receptors, Opioid, mu / Methadone / Narcotics / Neurons Limits: Animals / Humans Language: En Year: 2008 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptors, Opioid, mu / Methadone / Narcotics / Neurons Limits: Animals / Humans Language: En Year: 2008 Type: Article