Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice.

Buckley, Suzanne M K; Waddington, S N; Jezzard, S; Bergau, A; Themis, M; MacVinish, L J; Cuthbert, A W; Colledge, W H; Coutelle, C

Buckley, Suzanne M K; Waddington, S N; Jezzard, S; Bergau, A; Themis, M; MacVinish, L J; Cuthbert, A W; Colledge, W H; Coutelle, C.

Affiliation

Buckley SM; Department of Haematology, Haemophilia Centre and Thrombosis Unit, Royal Free & University College Medical School, London, UK. s.buckley@medsch.ucl.ac.uk

Mol Ther ; 16(5): 819-24, 2008 May.

Article in En | MEDLINE | ID: mdl-18388933

Subject(s)

Adenoviridae/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Cystic Fibrosis/genetics; Cystic Fibrosis/therapy; Gene Expression Regulation; Genetic Therapy/methods; Amniotic Fluid/metabolism; Animals; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Pregnancy; Pregnancy, Animal; Reproducibility of Results

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Full text: 1 Database: MEDLINE Main subject: Genetic Therapy / Adenoviridae / Gene Expression Regulation / Cystic Fibrosis Transmembrane Conductance Regulator / Cystic Fibrosis Type of study: Prognostic_studies Limits: Animals / Female / Humans / Pregnancy Language: En Year: 2008 Type: Article

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