Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.

Dueñas, Ana I; Aceves, Mónica; Fernández-Pisonero, Isabel; Gómez, Cristina; Orduña, Antonio; Crespo, Mariano Sánchez; García-Rodríguez, Carmen

Dueñas, Ana I; Aceves, Mónica; Fernández-Pisonero, Isabel; Gómez, Cristina; Orduña, Antonio; Crespo, Mariano Sánchez; García-Rodríguez, Carmen.

Affiliation

Dueñas AI; Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, C/Sanz y Forés s/n, 47003-Valladolid, Spain.

Cardiovasc Res ; 79(3): 537-44, 2008 Aug 01.

Article in En | MEDLINE | ID: mdl-18411230

Subject(s)

Atherosclerosis/prevention & control; Lysophospholipids/metabolism; Signal Transduction; Sphingosine/analogs & derivatives; Toll-Like Receptor 2/metabolism; Atherosclerosis/immunology; Atherosclerosis/metabolism; Cell Line; Chemokines/genetics; Chemokines/metabolism; Enzyme Inhibitors/pharmacology; Humans; Lipoproteins, HDL/metabolism; Lipoproteins, LDL/metabolism; NF-kappa B/metabolism; Phagocytes/metabolism; Phosphatidylcholines/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; RNA Interference; RNA, Small Interfering/metabolism; Receptors, Lysosphingolipid/genetics; Receptors, Lysosphingolipid/metabolism; Sphingosine/metabolism; Time Factors; Toll-Like Receptor 2/genetics; Transcription, Genetic; Transfection; ras Proteins/antagonists & inhibitors; ras Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Sphingosine / Lysophospholipids / Signal Transduction / Atherosclerosis / Toll-Like Receptor 2 Limits: Humans Language: En Year: 2008 Type: Article

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