Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms.
Chembiochem
; 9(8): 1267-79, 2008 May 23.
Article
in En
| MEDLINE
| ID: mdl-18431726
ABSTRACT
A 50-compound library based on the marine natural product oroidin was synthesized and assayed for anti-biofilm activity against PAO1 and PA14, two strains of the medically relevant gamma-proteobacterium Pseudomonas aeruginosa. Through structure-activity relationship (SAR) analysis of analogues based on the oroidin template, several conclusions can be drawn as to what structural properties of the synthetic derivatives are necessary to elicit a biological response. Notably, the most active analogues identified were those that contained a 2-aminoimidazole (2-AI) motif and a dibrominated pyrrolecarboxamide subunit. Here we disclose the synthesis and subsequently determined biological activity of this unique class of compounds as inhibitors of biofilm formation that have no direct antibiotic effect.
Full text:
1
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Pyrroles
/
Databases, Factual
/
Biofilms
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
En
Year:
2008
Type:
Article