Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells.

Hua, Xiaoyang; Chason, Kelly D; Fredholm, Bertil B; Deshpande, Deepak A; Penn, Raymond B; Tilley, Stephen L

Hua, Xiaoyang; Chason, Kelly D; Fredholm, Bertil B; Deshpande, Deepak A; Penn, Raymond B; Tilley, Stephen L.

Affiliation

Hua X; Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

J Allergy Clin Immunol ; 122(1): 107-13, 113.e1-7, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18472152

Subject(s)

Adenosine-5'-(N-ethylcarboxamide)/pharmacology; Adenosine/metabolism; Asthma/immunology; Bronchial Hyperreactivity/metabolism; Lung/metabolism; Mast Cells/metabolism; Receptor, Adenosine A3/metabolism; Animals; Asthma/chemically induced; Bronchial Hyperreactivity/chemically induced; Female; Hexosaminidases/metabolism; Lung/cytology; Lung/immunology; Mast Cells/drug effects; Mast Cells/immunology; Mice; Mice, Inbred C57BL; Receptor, Adenosine A3/deficiency

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Full text: 1 Database: MEDLINE Main subject: Asthma / Adenosine / Bronchial Hyperreactivity / Adenosine-5'-(N-ethylcarboxamide) / Receptor, Adenosine A3 / Lung / Mast Cells Limits: Animals Language: En Year: 2008 Type: Article

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