Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.

Binder, Michele D; Cate, Holly S; Prieto, Anne L; Kemper, Dennis; Butzkueven, Helmut; Gresle, Melissa M; Cipriani, Tania; Jokubaitis, Vilija G; Carmeliet, Peter; Kilpatrick, Trevor J

Binder, Michele D; Cate, Holly S; Prieto, Anne L; Kemper, Dennis; Butzkueven, Helmut; Gresle, Melissa M; Cipriani, Tania; Jokubaitis, Vilija G; Carmeliet, Peter; Kilpatrick, Trevor J.

Affiliation

Binder MD; Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

J Neurosci ; 28(20): 5195-206, 2008 May 14.

Article in En | MEDLINE | ID: mdl-18480276

Subject(s)

Demyelinating Diseases/genetics; Intercellular Signaling Peptides and Proteins/deficiency; Microglia/metabolism; Nerve Fibers, Myelinated/metabolism; Oligodendroglia/metabolism; Receptor Protein-Tyrosine Kinases/metabolism; Animals; Cell Death/genetics; Cell Survival/genetics; Cells, Cultured; Chelating Agents; Coculture Techniques; Cuprizone; Demyelinating Diseases/chemically induced; Demyelinating Diseases/physiopathology; Disease Models, Animal; Gliosis/genetics; Gliosis/metabolism; Gliosis/physiopathology; Intercellular Signaling Peptides and Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Myelinated/pathology; Neurotoxins; Oligodendroglia/pathology; Oncogene Proteins/metabolism; Proto-Oncogene Proteins/metabolism; Rats; Rats, Sprague-Dawley; c-Mer Tyrosine Kinase; Axl Receptor Tyrosine Kinase

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Full text: 1 Database: MEDLINE Main subject: Oligodendroglia / Demyelinating Diseases / Receptor Protein-Tyrosine Kinases / Microglia / Intercellular Signaling Peptides and Proteins / Nerve Fibers, Myelinated Type of study: Prognostic_studies Limits: Animals Language: En Year: 2008 Type: Article

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