Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database.
Ann Oncol
; 19(9): 1566-72, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18503039
ABSTRACT
Traditionally, matrix metalloproteinases (MMPs) have been implicated in cancer invasion and metastasis. Because of their role in these processes, several MMPs have been investigated for potential prognostic value as well as targets for antimetastatic therapy. In this investigation, we used a publically available database to relate messenger RNA expression levels for 17 different MMPs to tumor characteristics and outcome in patients with breast cancer. Of the MMPs investigated, only MMP-1 was significantly increased in tumors >2 cm in size compared with those
Full text:
1
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Biomarkers, Tumor
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Matrix Metalloproteinases
/
Neoplasm Invasiveness
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Year:
2008
Type:
Article