Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.

Dehmel, Florian; Weinbrenner, Steffen; Julius, Heiko; Ciossek, Thomas; Maier, Thomas; Stengel, Thomas; Fettis, Kamal; Burkhardt, Carmen; Wieland, Heike; Beckers, Thomas

Dehmel, Florian; Weinbrenner, Steffen; Julius, Heiko; Ciossek, Thomas; Maier, Thomas; Stengel, Thomas; Fettis, Kamal; Burkhardt, Carmen; Wieland, Heike; Beckers, Thomas.

Affiliation

Dehmel F; Nycomed GmbH, Therapeutic Area Oncology, Byk-Gulden-Strasse 2, D-78467 Konstanz, Germany.

J Med Chem ; 51(13): 3985-4001, 2008 Jul 10.

Article in En | MEDLINE | ID: mdl-18558669

Subject(s)

Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Histone Deacetylase Inhibitors; Thiones/chemical synthesis; Thiones/pharmacology; Acetylation; Cell Cycle/drug effects; Cell Survival/drug effects; Enzyme Inhibitors/chemistry; Histone Deacetylases/metabolism; Histones/metabolism; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/metabolism; Kinetics; Molecular Structure; Structure-Activity Relationship; Thiones/chemistry

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Full text: 1 Database: MEDLINE Main subject: Thiones / Enzyme Inhibitors / Histone Deacetylase Inhibitors Limits: Humans Language: En Year: 2008 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Thiones / Enzyme Inhibitors / Histone Deacetylase Inhibitors Limits: Humans Language: En Year: 2008 Type: Article