Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth.

Loeffler, Markus; Le'Negrate, Gaelle; Krajewska, Maryla; Reed, John C

Loeffler, Markus; Le'Negrate, Gaelle; Krajewska, Maryla; Reed, John C.

Affiliation

Loeffler M; Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Cancer Immunol Immunother ; 58(5): 769-75, 2009 May.

Article in En | MEDLINE | ID: mdl-18633610

Subject(s)

Adenocarcinoma/therapy; Bacterial Vaccines/therapeutic use; Cancer Vaccines/therapeutic use; Chemokine CCL21/physiology; Immunotherapy, Active; Melanoma, Experimental/therapy; Salmonella typhimurium/genetics; Adenocarcinoma/chemistry; Adenocarcinoma/immunology; Adenocarcinoma/prevention & control; Adenocarcinoma/secondary; Animals; Breast Neoplasms/pathology; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Cell Line, Tumor/transplantation; Chemokine CCL21/genetics; Chemokines/analysis; Colonic Neoplasms/pathology; Cytokines/analysis; Female; Lung Neoplasms/chemistry; Lung Neoplasms/immunology; Lung Neoplasms/prevention & control; Lung Neoplasms/secondary; Lung Neoplasms/therapy; Lymphocytes, Tumor-Infiltrating/immunology; Melanoma, Experimental/chemistry; Melanoma, Experimental/immunology; Mice; Mice, Inbred BALB C; Recombinant Fusion Proteins/physiology; Salmonella typhimurium/metabolism; Vaccines, Attenuated/therapeutic use; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Salmonella typhimurium / Melanoma, Experimental / Bacterial Vaccines / Adenocarcinoma / Immunotherapy, Active / Cancer Vaccines / Chemokine CCL21 Limits: Animals Language: En Year: 2009 Type: Article

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