Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs.

Xu, Da-Zhong; Zaets, Sergey B; Chen, Ruihua; Lu, Qi; Rajan, Harini; Yang, Xiaoman; Zhang, John; Feketova, Eleonora; Bogdan, Nancy; Deitch, Edwin A; Cao, Yang

Xu, Da-Zhong; Zaets, Sergey B; Chen, Ruihua; Lu, Qi; Rajan, Harini; Yang, Xiaoman; Zhang, John; Feketova, Eleonora; Bogdan, Nancy; Deitch, Edwin A; Cao, Yang.

Affiliation

Xu DZ; Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.

Shock ; 31(5): 493-9, 2009 May.

Article in En | MEDLINE | ID: mdl-18791492

Subject(s)

Intestinal Mucosa/blood supply; Neutrophil Infiltration/physiology; Receptor, Anaphylatoxin C5a/physiology; Reperfusion Injury/prevention & control; Animals; Apoptosis; Disease Models, Animal; Ileum/blood supply; Ileum/metabolism; Intestinal Mucosa/metabolism; Lung/blood supply; Lung/metabolism; Mice; Mice, Knockout; Neutrophil Infiltration/genetics; Peroxidase/metabolism; Receptor, Anaphylatoxin C5a/genetics; Reperfusion Injury/genetics; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha/blood

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Full text: 1 Database: MEDLINE Main subject: Reperfusion Injury / Neutrophil Infiltration / Receptor, Anaphylatoxin C5a / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals Language: En Year: 2009 Type: Article

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