PKC-theta selectively controls the adhesion-stimulating molecule Rap1.

Letschka, Thomas; Kollmann, Veronika; Pfeifhofer-Obermair, Christa; Lutz-Nicoladoni, Christina; Obermair, Gerald J; Fresser, Friedrich; Leitges, Michael; Hermann-Kleiter, Natascha; Kaminski, Sandra; Baier, Gottfried

Letschka, Thomas; Kollmann, Veronika; Pfeifhofer-Obermair, Christa; Lutz-Nicoladoni, Christina; Obermair, Gerald J; Fresser, Friedrich; Leitges, Michael; Hermann-Kleiter, Natascha; Kaminski, Sandra; Baier, Gottfried.

Affiliation

Letschka T; Department for Medical Genetics, Innsbruck Medical University, Innsbruck, Austria.

Blood ; 112(12): 4617-27, 2008 Dec 01.

Article in En | MEDLINE | ID: mdl-18796635

Subject(s)

Cell Adhesion/genetics; Isoenzymes/physiology; Protein Kinase C/physiology; T-Lymphocytes/physiology; rap1 GTP-Binding Proteins/metabolism; Animals; Cell Adhesion/drug effects; Guanine Nucleotide Exchange Factors/antagonists & inhibitors; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; Humans; Isoenzymes/genetics; Isoenzymes/metabolism; Jurkat Cells; Lymphocyte Function-Associated Antigen-1/physiology; Mice; Mice, Knockout; Nerve Tissue Proteins/antagonists & inhibitors; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Phosphorylation; Protein Binding; Protein Kinase C/genetics; Protein Kinase C/metabolism; Protein Kinase C-theta; RNA, Small Interfering/pharmacology; Substrate Specificity; T-Lymphocytes/drug effects; T-Lymphocytes/metabolism; Up-Regulation/genetics; Up-Regulation/physiology

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Full text: 1 Database: MEDLINE Main subject: Protein Kinase C / T-Lymphocytes / Cell Adhesion / Rap1 GTP-Binding Proteins / Isoenzymes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2008 Type: Article

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