Total synthesis of amphidinolide J.
Org Lett
; 10(20): 4489-92, 2008 Oct 16.
Article
in En
| MEDLINE
| ID: mdl-18811171
ABSTRACT
The marine natural product amphidinolide J has been synthesized according to a convergent strategy. The key steps of this synthesis include a B-alkyl Suzuki-Miyaura coupling and the addition of an alkynyllithium reagent to a Weinreb amide to build the C4-C5 and C12-C13 bonds, respectively, and a Yamaguchi macrolactonization.
Full text:
1
Database:
MEDLINE
Main subject:
Macrolides
Language:
En
Year:
2008
Type:
Article