5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).

Winters, Michael P; Robinson, Darius J; Khine, Hnin Hnin; Pullen, Steven S; Woska, Joseph R; Raymond, Ernest L; Sellati, Rosemarie; Cywin, Charles L; Snow, Roger J; Kashem, Mohammed A; Wolak, John P; King, Josephine; Kaplita, Paul V; Liu, Lisa H; Farrell, Thomas M; DesJarlais, Renee; Roth, Gregory P; Takahashi, Hidenori; Moriarty, Kevin J

Winters, Michael P; Robinson, Darius J; Khine, Hnin Hnin; Pullen, Steven S; Woska, Joseph R; Raymond, Ernest L; Sellati, Rosemarie; Cywin, Charles L; Snow, Roger J; Kashem, Mohammed A; Wolak, John P; King, Josephine; Kaplita, Paul V; Liu, Lisa H; Farrell, Thomas M; DesJarlais, Renee; Roth, Gregory P; Takahashi, Hidenori; Moriarty, Kevin J.

Affiliation

Winters MP; Johnson & Johnson Pharmaceutical Research and Development, 665 Stockton Drive, Exton, PA 19341, USA.

Bioorg Med Chem Lett ; 18(20): 5541-4, 2008 Oct 15.

Article in En | MEDLINE | ID: mdl-18823779

Subject(s)

Benzimidazoles/administration & dosage; Benzimidazoles/chemistry; Benzimidazoles/chemical synthesis; Chemistry, Pharmaceutical/methods; Protein-Tyrosine Kinases/antagonists & inhibitors; Protein-Tyrosine Kinases/chemistry; Administration, Oral; Animals; Benzimidazoles/pharmacology; CD3 Complex/biosynthesis; Drug Design; Humans; Inhibitory Concentration 50; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Models, Chemical; Structure-Activity Relationship; T-Lymphocytes/cytology

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Full text: 1 Database: MEDLINE Main subject: Benzimidazoles / Protein-Tyrosine Kinases / Chemistry, Pharmaceutical Limits: Animals / Humans Language: En Year: 2008 Type: Article

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