A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain.

Moon, Bo-Hyun; Hong, Chang Gwun; Kim, Soo-Young; Kim, Hyun-Ju; Shin, Seung Keon; Kang, Seungwoo; Lee, Kuem-Ju; Kim, Yong-Ku; Lee, Min-Soo; Shin, Kyung-Ho

Moon, Bo-Hyun; Hong, Chang Gwun; Kim, Soo-Young; Kim, Hyun-Ju; Shin, Seung Keon; Kang, Seungwoo; Lee, Kuem-Ju; Kim, Yong-Ku; Lee, Min-Soo; Shin, Kyung-Ho.

Affiliation

Moon BH; Department of Pharmacology and Division of Brain Korea 21, Biomedical Science, Korea University College of Medicine, 126-1, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-705, Republic of Korea.

Toxicol Appl Pharmacol ; 233(2): 314-22, 2008 Dec 01.

Article in En | MEDLINE | ID: mdl-18824019

Subject(s)

Drinking/drug effects; Eating/drug effects; Environmental Pollutants/toxicity; Gene Expression Regulation/drug effects; Polychlorinated Dibenzodioxins/toxicity; Animals; Arginine Vasopressin/drug effects; Arginine Vasopressin/metabolism; Corticotropin-Releasing Hormone/drug effects; Corticotropin-Releasing Hormone/metabolism; Dose-Response Relationship, Drug; Environmental Pollutants/administration & dosage; Hypothalamus/drug effects; Hypothalamus/metabolism; Male; Polychlorinated Dibenzodioxins/administration & dosage; Pro-Opiomelanocortin/drug effects; Pro-Opiomelanocortin/metabolism; RNA, Messenger/drug effects; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Gene Expression Regulation / Drinking / Eating / Environmental Pollutants / Polychlorinated Dibenzodioxins Limits: Animals Language: En Year: 2008 Type: Article

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