Isolated extra-medullary relapse of acute leukemia following allogeneic bone marrow transplantation.

Firas, Al Sabty; Demeckova, E; Bojtarova, E; Czako, B; Hrubisko, M; Mistrik, M

Firas, Al Sabty; Demeckova, E; Bojtarova, E; Czako, B; Hrubisko, M; Mistrik, M.

Affiliation

Firas AS; Department of Hematology and Transfusion Medicine, Faculty of Medicine, University Hospital, Comenius University, Bratislava, Slovakia. firasalsabty@yahoo.com

Bratisl Lek Listy ; 109(8): 358-61, 2008.

Article in En | MEDLINE | ID: mdl-18837244

ABSTRACT

ABSTRACT

Isolated extramedullary relapse (IEMR) of acute leukemia (AL) after allogeneic bone marrow transplantation (BMT) is a rare occurrence. It is seen more commonly after BMT than after conventional chemotherapy (CHT) alone. We describe the natural history and response to treatment in four patients with IEMR following allogeneic BMT. The results indicate a stronger graft-versus-leukemia (GVL) effect in the marrow than in the peripheral tissues (Fig. 4, Ref. 13). Full Text (Free, PDF) www.bmj.sk.

Subject(s)

Bone Marrow Transplantation/adverse effects; Leukemia, Myeloid, Acute/surgery; Leukemic Infiltration/etiology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/surgery; Adult; Brain/pathology; Breast/pathology; Female; Graft vs Leukemia Effect; Humans; Leukemic Infiltration/pathology; Middle Aged; Skin/pathology; Transplantation, Homologous/adverse effects

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Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Bone Marrow Transplantation / Leukemic Infiltration / Precursor Cell Lymphoblastic Leukemia-Lymphoma Limits: Adult / Female / Humans / Middle aged Language: En Year: 2008 Type: Article

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