Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?

Maher, B M; Dhonnchu, T Ni; Burke, J P; Soo, A; Wood, A E; Watson, R W G

Maher, B M; Dhonnchu, T Ni; Burke, J P; Soo, A; Wood, A E; Watson, R W G.

Affiliation

Maher BM; University College Dublin School of Medicine and Medical Sciences, UCD Conway Institute and Professor Eoin O'Malley National Centre for Cardiothoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland. belinda.maher@ucd.ie

J Leukoc Biol ; 85(1): 186-93, 2009 Jan.

Article in En | MEDLINE | ID: mdl-18840670

Subject(s)

Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Neutrophils/drug effects; rhoA GTP-Binding Protein/physiology; Atorvastatin; Cells, Cultured; Chemotactic Factors/pharmacology; Endothelial Cells/cytology; Endothelial Cells/metabolism; Endothelium, Vascular/cytology; Heptanoic Acids/pharmacology; Humans; N-Formylmethionine Leucyl-Phenylalanine/pharmacology; Neutrophil Infiltration/drug effects; Neutrophil Infiltration/physiology; Neutrophils/physiology; Polyisoprenyl Phosphates/metabolism; Pravastatin/pharmacology; Pyrroles/pharmacology; Simvastatin/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / RhoA GTP-Binding Protein / Neutrophils Limits: Humans Language: En Year: 2009 Type: Article

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