Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.

Velmurugan, Kalpana; Alam, Jawed; McCord, Joe M; Pugazhenthi, Subbiah

Velmurugan, Kalpana; Alam, Jawed; McCord, Joe M; Pugazhenthi, Subbiah.

Affiliation

Velmurugan K; Division of Endocrinology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

Free Radic Biol Med ; 46(3): 430-40, 2009 Feb 01.

Article in En | MEDLINE | ID: mdl-19056485

Subject(s)

Antioxidants/pharmacology; Enzyme Induction/drug effects; Heme Oxygenase-1/metabolism; NF-E2-Related Factor 2/metabolism; Active Transport, Cell Nucleus/drug effects; Animals; Antioxidants/chemistry; Cell Line; Cell Nucleus/metabolism; Curcumin/pharmacology; Dose-Response Relationship, Drug; Drug Synergism; Drugs, Chinese Herbal/chemistry; Drugs, Chinese Herbal/pharmacology; Glutathione/genetics; Glutathione/metabolism; Heme Oxygenase-1/genetics; Humans; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/enzymology; Mice; NF-E2-Related Factor 2/genetics; Pharmaceutical Preparations/chemistry; Phosphatidylinositol 3-Kinases/metabolism; Promoter Regions, Genetic; Protein Kinase C-delta/metabolism; Response Elements/drug effects; Signal Transduction; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Enzyme Induction / Heme Oxygenase-1 / NF-E2-Related Factor 2 / Antioxidants Limits: Animals / Humans Language: En Year: 2009 Type: Article

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