cDNA analysis demonstrates that the BRCA2 intronic variant IVS4-12del5 is a deleterious mutation.

Zhang, Liying; Bacares, Ruben; Boyar, Sherry; Hudis, Clifford; Nafa, Khedoudja; Offit, Kenneth

Zhang, Liying; Bacares, Ruben; Boyar, Sherry; Hudis, Clifford; Nafa, Khedoudja; Offit, Kenneth.

Affiliation

Zhang L; Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Mutat Res ; 663(1-2): 84-9, 2009 Apr 26.

Article in En | MEDLINE | ID: mdl-19070627

Subject(s)

BRCA2 Protein/genetics; DNA, Complementary/genetics; Introns/genetics; Mutation/genetics; Adult; Aged; Alleles; Alternative Splicing/genetics; Base Sequence; Chromosome Segregation; DNA Mutational Analysis; Exons/genetics; Female; Humans; Loss of Heterozygosity/genetics; Male; Middle Aged; Molecular Sequence Data; Pedigree; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Alignment

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Full text: 1 Database: MEDLINE Main subject: Introns / DNA, Complementary / BRCA2 Protein / Mutation Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2009 Type: Article

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