P16 expression in odontogenic tumors.
Tumori
; 94(5): 718-23, 2008.
Article
in En
| MEDLINE
| ID: mdl-19112947
ABSTRACT
AIMS AND BACKGROUND:
The aim of the study was to examine the immunohistochemical expression of a cell-cycle-related factor (p16) in order to elucidate its role in the growth and diffusion of odontogenic tumors. STUDYDESIGN:
Thirty-six odontogenic tumors were divided into two groups according to their clinical behavior group A and group B composed of tumors at low and high risk of recurrences, respectively. The ANOVA test was used to detect differences between the two groups.RESULTS:
p16 was expressed in both groups, but with different localization. A statistically significant difference was found in p16 expression of peripheral cells, with an increase in the expression in group B compared to group A (P < 0.05). In addition, there was no significant difference in p16 positive expression of the central cells of odontogenic tumors, which was high in both groups.CONCLUSIONS:
The present data show a correlation between p16 expression and the biological behavior of odontogenic tumors.
Search on Google
Database:
MEDLINE
Main subject:
Odontogenic Tumors
/
Biomarkers, Tumor
/
Neoplasm Proteins
Type of study:
Etiology_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2008
Type:
Article