A short entry to alpha-substituted gamma-alkylidene pentenolides. Synthesis and preliminary biological evaluation of novel gelastatin analogues.
J Org Chem
; 74(2): 703-9, 2009 Jan 16.
Article
in En
| MEDLINE
| ID: mdl-19143092
ABSTRACT
Biologically interesting 2-substituted 4-alkylidene pentenolides were prepared with complete control of regio- and stereoselectivity from 2-iodo allylic alcohols via an array of Pd-catalyzed processes, including alkynylation with methyl propiolate, tributyltin hydride addition, and alpha-functionalization. Some of the compounds possess selective cytostatic activity against ovarian carcinoma HeLa S3 and leukemia CCRF-CEM cell lines.
Full text:
1
Database:
MEDLINE
Main subject:
Propionates
/
Alkenes
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Year:
2009
Type:
Article