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A short entry to alpha-substituted gamma-alkylidene pentenolides. Synthesis and preliminary biological evaluation of novel gelastatin analogues.
Pavlík, Jan; Snajdr, Ivan; Kunes, Jirí; Spulák, Marcel; Pour, Milan.
Affiliation
  • Pavlík J; Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 05 Hradec Králové, Czech Republic.
J Org Chem ; 74(2): 703-9, 2009 Jan 16.
Article in En | MEDLINE | ID: mdl-19143092
ABSTRACT
Biologically interesting 2-substituted 4-alkylidene pentenolides were prepared with complete control of regio- and stereoselectivity from 2-iodo allylic alcohols via an array of Pd-catalyzed processes, including alkynylation with methyl propiolate, tributyltin hydride addition, and alpha-functionalization. Some of the compounds possess selective cytostatic activity against ovarian carcinoma HeLa S3 and leukemia CCRF-CEM cell lines.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Propionates / Alkenes / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2009 Type: Article

Full text: 1 Database: MEDLINE Main subject: Propionates / Alkenes / Antineoplastic Agents Limits: Animals / Humans Language: En Year: 2009 Type: Article