Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response.

Carlin, Aaron F; Uchiyama, Satoshi; Chang, Yung-Chi; Lewis, Amanda L; Nizet, Victor; Varki, Ajit

Carlin, Aaron F; Uchiyama, Satoshi; Chang, Yung-Chi; Lewis, Amanda L; Nizet, Victor; Varki, Ajit.

Affiliation

Carlin AF; Department of Medicine, Pediatrics, and Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0687, USA.

Blood ; 113(14): 3333-6, 2009 Apr 02.

Article in En | MEDLINE | ID: mdl-19196661

Subject(s)

Antigens, CD/metabolism; Bacteria/metabolism; Immunity, Innate; Lectins/metabolism; Molecular Mimicry/physiology; Neutrophils/metabolism; Polysaccharides/immunology; Antigens, CD/immunology; Antigens, CD/physiology; Bacteria/immunology; Cell Adhesion/immunology; Cells, Cultured; Host-Pathogen Interactions/immunology; Humans; Immune Tolerance/immunology; Immunity, Innate/physiology; Lectins/immunology; Lectins/physiology; Molecular Mimicry/immunology; Neutrophils/immunology; Polysaccharides/physiology; Polysaccharides, Bacterial/immunology; Polysaccharides, Bacterial/metabolism; Sialic Acid Binding Immunoglobulin-like Lectins; Sialic Acids/immunology; Sialic Acids/physiology; Streptococcus agalactiae/immunology; Streptococcus agalactiae/metabolism

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Full text: 1 Database: MEDLINE Main subject: Polysaccharides / Bacteria / Antigens, CD / Molecular Mimicry / Immunity, Innate / Lectins / Neutrophils Limits: Humans Language: En Year: 2009 Type: Article

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