Pharmacokinetic study of sodium trans[tetrachlorobis(1H-indazole)-ruthenate (III)]/-indazole hydrochloride (1:1.1) (FFC14A) in patients with solid tumors.

Henke, M M; Richly, H; Drescher, A; Grubert, M; Alex, D; Thyssen, D; Jaehde, U; Scheulen, M E; Hilger, R A

Henke, M M; Richly, H; Drescher, A; Grubert, M; Alex, D; Thyssen, D; Jaehde, U; Scheulen, M E; Hilger, R A.

Affiliation

Henke MM; Universitatsklinikum Essen, Essen, Germany. magdalena.henke@uni.essen.de

Int J Clin Pharmacol Ther ; 47(1): 58-60, 2009 Jan.

Article in En | MEDLINE | ID: mdl-19203540

Subject(s)

Antineoplastic Agents/pharmacokinetics; Indazoles/pharmacokinetics; Neoplasms/metabolism; Ruthenium Compounds/pharmacokinetics; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/chemistry; Antineoplastic Agents/therapeutic use; Biomarkers/blood; Biomarkers/chemistry; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; DNA Adducts/blood; DNA Adducts/chemistry; Dose-Response Relationship, Drug; Half-Life; Humans; Indazoles/administration & dosage; Indazoles/chemistry; Indazoles/therapeutic use; Infusions, Intravenous; Leukocytes/chemistry; Metabolic Clearance Rate; Neoplasms/drug therapy; Organometallic Compounds; Ruthenium Compounds/administration & dosage; Ruthenium Compounds/chemistry; Ruthenium Compounds/therapeutic use; Serum Albumin/analysis; Serum Albumin/chemistry; Serum Albumin/metabolism; Transferrin/analysis; Transferrin/chemistry; Transferrin/metabolism

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PubMed Links

Database: MEDLINE Main subject: Ruthenium Compounds / Indazoles / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Year: 2009 Type: Article

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XML

PubMed Links

Database: MEDLINE Main subject: Ruthenium Compounds / Indazoles / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Year: 2009 Type: Article