Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling.

Li, Ying-Hua; Wang, Yin-Yin; Zhong, Shan; Rong, Zhi-Li; Ren, Yong-Ming; Li, Zhi-Yong; Zhang, Shu-Ping; Chang, Zhi-Jie; Liu, Li

Li, Ying-Hua; Wang, Yin-Yin; Zhong, Shan; Rong, Zhi-Li; Ren, Yong-Ming; Li, Zhi-Yong; Zhang, Shu-Ping; Chang, Zhi-Jie; Liu, Li.

Affiliation

Li YH; Institute of Biomedicine and School of Medicine, Tsinghua University, Beijing, 100084, China.

Mol Cells ; 27(1): 39-45, 2009 Jan 31.

Article in En | MEDLINE | ID: mdl-19214432

Subject(s)

Cell Membrane/enzymology; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases/metabolism; Protein Multimerization; Receptor Protein-Tyrosine Kinases/chemistry; Receptor Protein-Tyrosine Kinases/metabolism; ras Proteins/metabolism; Animals; COS Cells; Chlorocebus aethiops; Humans; Mutant Proteins/metabolism; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Structure-Activity Relationship; Subcellular Fractions/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Cell Membrane / Receptor Protein-Tyrosine Kinases / Ras Proteins / Mitogen-Activated Protein Kinases / MAP Kinase Signaling System / Protein Multimerization Limits: Animals / Humans Language: En Year: 2009 Type: Article

Fulltext

XML

PubMed Links

Search on Google