Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy.

Zhang, Zhen; Alpert, Deanne; Francis, Richard; Chatterjee, Bishwanath; Yu, Qing; Tansey, Terry; Sabol, Steven L; Cui, Cheng; Bai, Yongli; Koriabine, Maxim; Yoshinaga, Yuko; Cheng, Jan-Fang; Chen, Feng; Martin, Joel; Schackwitz, Wendy; Gunn, Teresa M; Kramer, Kenneth L; De Jong, Pieter J; Pennacchio, Len A; Lo, Cecilia W

Zhang, Zhen; Alpert, Deanne; Francis, Richard; Chatterjee, Bishwanath; Yu, Qing; Tansey, Terry; Sabol, Steven L; Cui, Cheng; Bai, Yongli; Koriabine, Maxim; Yoshinaga, Yuko; Cheng, Jan-Fang; Chen, Feng; Martin, Joel; Schackwitz, Wendy; Gunn, Teresa M; Kramer, Kenneth L; De Jong, Pieter J; Pennacchio, Len A; Lo, Cecilia W.

Affiliation

Zhang Z; Laboratory of Developmental Biology, National Heart Lung and Blood Institute, Bethesda, MD 20892-1583, USA.

Proc Natl Acad Sci U S A ; 106(9): 3219-24, 2009 Mar 03.

Article in En | MEDLINE | ID: mdl-19218456

Subject(s)

Body Patterning; Ethylnitrosourea/pharmacology; Membrane Proteins/metabolism; Zebrafish Proteins/metabolism; Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/embryology; Embryo, Nonmammalian/metabolism; Gene Expression Regulation, Developmental/drug effects; Humans; Membrane Proteins/chemistry; Membrane Proteins/genetics; Molecular Sequence Data; Mutation/genetics; Nodal Protein/metabolism; Sequence Alignment; Signal Transduction; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/chemistry; Zebrafish Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Body Patterning / Zebrafish Proteins / Ethylnitrosourea / Membrane Proteins Limits: Animals / Humans Language: En Year: 2009 Type: Article

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