Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells.

Robertson, Fredika M; Simeone, Ann-Marie; Mazumdar, Abhijit; Shah, Ashish H; McMurray, John S; Ghosh, Sukhen; Cristofanilli, Massimo

Robertson, Fredika M; Simeone, Ann-Marie; Mazumdar, Abhijit; Shah, Ashish H; McMurray, John S; Ghosh, Sukhen; Cristofanilli, Massimo.

Affiliation

Robertson FM; Department of Experimental Therapeutics, 1515 Holcombe Blvd, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. frobertson@mdanderson.org

J Exp Ther Oncol ; 7(4): 299-312, 2008.

Article in En | MEDLINE | ID: mdl-19227010

Subject(s)

Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Gene Expression Regulation, Neoplastic; Receptors, Prostaglandin E/antagonists & inhibitors; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2/metabolism; Dinoprostone/metabolism; Drug Screening Assays, Antitumor; Humans; Isoindoles/pharmacology; Models, Biological; Neoplasm Invasiveness; Receptors, Prostaglandin E, EP4 Subtype; Sulfonamides/pharmacology; Time Factors

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Database: MEDLINE Main subject: Breast Neoplasms / Gene Expression Regulation, Neoplastic / Receptors, Prostaglandin E Type of study: Prognostic_studies Limits: Humans Language: En Year: 2008 Type: Article

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