Critical periods for the teratogenicity of immune-suppressant Leflunomide in mice.

Fukushima, Ryou; Kanamori, Susumu; Hirashiba, Masahiro; Hishikawa, Atsuko; Muranaka, Ri-ichi; Kaneto, Masako; Kitagawa, Hiroshi

Fukushima, Ryou; Kanamori, Susumu; Hirashiba, Masahiro; Hishikawa, Atsuko; Muranaka, Ri-ichi; Kaneto, Masako; Kitagawa, Hiroshi.

Affiliation

Fukushima R; Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co. Ltd., Osaka, Japan. ryou.fukushima@shionogi.co.jp

Congenit Anom (Kyoto) ; 49(1): 20-6, 2009 Mar.

Article in En | MEDLINE | ID: mdl-19243413

Subject(s)

Abnormalities, Drug-Induced; Abnormalities, Multiple/pathology; Embryo, Mammalian/drug effects; Fetal Viability/drug effects; Immunosuppressive Agents/toxicity; Isoxazoles/toxicity; Adjuvants, Immunologic/toxicity; Animals; Critical Period, Psychological; Embryo Loss; Embryo, Mammalian/cytology; Female; Gestational Age; Leflunomide; Male; Mice; Mice, Inbred ICR; Pregnancy

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Full text: 1 Database: MEDLINE Main subject: Abnormalities, Drug-Induced / Abnormalities, Multiple / Embryo, Mammalian / Fetal Viability / Immunosuppressive Agents / Isoxazoles Limits: Animals / Pregnancy Language: En Year: 2009 Type: Article

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