Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.

Kalgutkar, Amit S; Bauman, Jonathan N; McClure, Kim F; Aubrecht, Jiri; Cortina, Santo R; Paralkar, Janvi

Kalgutkar, Amit S; Bauman, Jonathan N; McClure, Kim F; Aubrecht, Jiri; Cortina, Santo R; Paralkar, Janvi.

Affiliation

Kalgutkar AS; Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.

Bioorg Med Chem Lett ; 19(6): 1559-63, 2009 Mar 15.

Article in En | MEDLINE | ID: mdl-19246199

Subject(s)

Chemistry, Pharmaceutical/methods; Piperazines/chemistry; Serotonin 5-HT2 Receptor Agonists; Amides/chemistry; Chromatography/methods; Drug Design; Models, Chemical; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation; NADP/chemistry; Piperazine; Reproducibility of Results; Salmonella/metabolism

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Full text: 1 Database: MEDLINE Main subject: Piperazines / Chemistry, Pharmaceutical / Serotonin 5-HT2 Receptor Agonists Type of study: Prognostic_studies Language: En Year: 2009 Type: Article

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