Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation.

Leong, Su Ling; Pham, Chi L L; Galatis, Denise; Fodero-Tavoletti, Michelle T; Perez, Keyla; Hill, Andrew F; Masters, Colin L; Ali, Feda E; Barnham, Kevin J; Cappai, Roberto

Leong, Su Ling; Pham, Chi L L; Galatis, Denise; Fodero-Tavoletti, Michelle T; Perez, Keyla; Hill, Andrew F; Masters, Colin L; Ali, Feda E; Barnham, Kevin J; Cappai, Roberto.

Affiliation

Leong SL; Department of Pathology, The University of Melbourne, Parkville, VIC, Australia.

Free Radic Biol Med ; 46(10): 1328-37, 2009 May 15.

Article in En | MEDLINE | ID: mdl-19248830

Subject(s)

Dopamine/metabolism; Neurons/metabolism; Parkinson Disease/physiopathology; Protein Multimerization; alpha-Synuclein/metabolism; Amino Acid Motifs/genetics; Chromatography, High Pressure Liquid; Cloning, Molecular; Humans; Lewy Bodies/metabolism; Methionine/metabolism; Mutagenesis, Site-Directed; Neurons/ultrastructure; Oxidation-Reduction; Oxidative Stress; Parkinson Disease/pathology; Peptides/genetics; Peptides/metabolism; Protein Binding; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; alpha-Synuclein/genetics

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Full text: 1 Database: MEDLINE Main subject: Parkinson Disease / Dopamine / Alpha-Synuclein / Protein Multimerization / Neurons Limits: Humans Language: En Year: 2009 Type: Article

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