Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network.

Tu, Zhidong; Argmann, Carmen; Wong, Kenny K; Mitnaul, Lyndon J; Edwards, Stephen; Sach, Iliana C; Zhu, Jun; Schadt, Eric E

Tu, Zhidong; Argmann, Carmen; Wong, Kenny K; Mitnaul, Lyndon J; Edwards, Stephen; Sach, Iliana C; Zhu, Jun; Schadt, Eric E.

Affiliation

Tu Z; Rosetta Inpharmatics, a wholly owned subsidiary of Merck & Co., Inc., Seattle, Washington 98109, USA.

Genome Res ; 19(6): 1057-67, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19261841

Subject(s)

Insulin/pharmacology; Protein Interaction Mapping/methods; RNA, Small Interfering/genetics; Signal Transduction/genetics; 3T3-L1 Cells; Adipocytes/cytology; Adipocytes/drug effects; Adipocytes/metabolism; Animals; Animals, Newborn; Databases, Genetic; Diabetes Mellitus, Type 2/genetics; Diabetes Mellitus, Type 2/metabolism; Fatty Acids, Nonesterified/metabolism; Female; Gene Regulatory Networks; Hypoglycemic Agents/pharmacology; Insulin Resistance/genetics; Male; Mice; Mice, Knockout; Models, Genetic; Receptors, Lysosphingolipid/genetics; Receptors, Lysosphingolipid/metabolism; Sphingosine-1-Phosphate Receptors; Transfection

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Protein Interaction Mapping / RNA, Small Interfering / Insulin Type of study: Prognostic_studies Limits: Animals Language: En Year: 2009 Type: Article

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