Inhibition of cAMP degradation improves regulatory T cell-mediated suppression.

Bopp, Tobias; Dehzad, Nina; Reuter, Sebastian; Klein, Matthias; Ullrich, Nina; Stassen, Michael; Schild, Hansjörg; Buhl, Roland; Schmitt, Edgar; Taube, Christian

Bopp, Tobias; Dehzad, Nina; Reuter, Sebastian; Klein, Matthias; Ullrich, Nina; Stassen, Michael; Schild, Hansjörg; Buhl, Roland; Schmitt, Edgar; Taube, Christian.

Affiliation

Bopp T; Institute for Immunology, Johannes Gutenberg-University, Mainz, Germany.

J Immunol ; 182(7): 4017-24, 2009 Apr 01.

Article in En | MEDLINE | ID: mdl-19299699

Subject(s)

Cyclic AMP/immunology; Cyclic AMP/metabolism; Hypersensitivity/immunology; Immune Tolerance/immunology; T-Lymphocytes, Regulatory/immunology; Animals; Cells, Cultured; Coculture Techniques; Cyclic Nucleotide Phosphodiesterases, Type 4/drug effects; Cyclic Nucleotide Phosphodiesterases, Type 4/immunology; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immune Tolerance/drug effects; Lung Diseases/drug therapy; Lung Diseases/immunology; Lung Diseases/pathology; Mice; Mice, Transgenic; Phosphodiesterase Inhibitors/pharmacology; Rolipram/pharmacology; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/metabolism; Th2 Cells/immunology

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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Cyclic AMP / Hypersensitivity / Immune Tolerance Limits: Animals Language: En Year: 2009 Type: Article

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