The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator.
J Biol Regul Homeost Agents
; 23(1): 11-4, 2009.
Article
in En
| MEDLINE
| ID: mdl-19321041
ABSTRACT
IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.
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Database:
MEDLINE
Main subject:
Interleukins
/
Interleukin-1
/
Mast Cells
Limits:
Animals
Language:
En
Year:
2009
Type:
Article