A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes.

Chamorro, Cristina; Kruijtzer, John A W; Farsaraki, Marina; Balzarini, Jan; Liskamp, Rob M J

Chamorro, Cristina; Kruijtzer, John A W; Farsaraki, Marina; Balzarini, Jan; Liskamp, Rob M J.

Affiliation

Chamorro C; Medicinal Chemistry & Chemical Biology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB, Utrecht, The Netherlands.

Chem Commun (Camb) ; (7): 821-3, 2009 Feb 21.

Article in En | MEDLINE | ID: mdl-19322453

ABSTRACT

ABSTRACT

In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.

Subject(s)

Aza Compounds/chemistry; Biomimetics; Epitopes/chemistry; Heterocyclic Compounds, 2-Ring/chemistry; Proteins/chemical synthesis; Amino Acid Sequence; Antibodies; Mass Spectrometry; Models, Molecular; Peptides, Cyclic/chemistry; Protein Conformation; Proteins/chemistry

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Full text: 1 Database: MEDLINE Main subject: Aza Compounds / Proteins / Biomimetics / Heterocyclic Compounds, 2-Ring / Epitopes Language: En Year: 2009 Type: Article

Fulltext

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PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Aza Compounds / Proteins / Biomimetics / Heterocyclic Compounds, 2-Ring / Epitopes Language: En Year: 2009 Type: Article